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What is Arthritis? – Arthritis and Systemic Enzymes

Treatment options with serious side effects have led to an increasing use of systemic enzyme therapy as a means to alleviate symptoms and improve quality of life. Certain proteolytic (protein digesting) enzymes have been identified to have extremely beneficial actions when applied to inflammation and pain related to this condition. Systemic enzymes, typically taken orally and on an empty stomach, enter directly into the blood stream. Enzymes can then circulate throughout the body, acting upon complexes in the blood as well as in tissues and organs. 

Systemic enzymes have successfully demonstrated the ability to reduce signs of pain throughout the body. Serrapeptase, an enzyme extracted from silk worms, has been evaluated in numerous studies for its effectiveness in pain reduction and shown favorable results.

The use of systemic enzymes in treating pain throughout the body was evaluated in several clinical studies. Rheumatic conditions, including periarthritis of the shoulder, painful osteoarthritis of the knee and vertebral syndromes, were evaluated based on pain scores before and after treatment with proteolytic enzymes and non-steroidal anti-inflammatory drugs (NSAIDs). Evidence showed a statistical equivalence between oral enzyme therapy and conventional drug therapy in the ability to significantly reduce pain in various rheumatic diseases.1

Researchers in India conducted a study to assess the response of serrapeptase in patients with carpal tunnel syndrome (CTS). Twenty patients with CTS were evaluated clinically after six weeks of taking serrapeptase. Sixty-five percent showed significant clinical improvement, which was supported by improvement in electrophysiological parameters (measurements of nerve activity). The doctors concluded that serrapeptase therapy may prove to be a useful alternative conservative treatment.2

Another study was conducted comparing the efficacy of two proteolytic enzymes in the treatment of venous inflammatory disease. The efficacy of Serrapeptase and Seaprose S (a protease) was assessed using good or excellent results as the measure of effective treatment. Serrapeptase was effective in 65 percent of the cases compared to 85 percent for Seaprose S. Serrapeptase specifically demonstrated a 63 percent reduction in spontaneous pain and 57 percent reduction in pain on pressure. Though Seaprose S had better overall results, both enzymes were effective. It can thus be confirmed that both enzymes were effective in patients with inflammatory venous disease.3 (Note: Seaprose S has since been withdrawn from the market).

A prospective study was conducted on the effect of serrapeptase on post-operative swelling and pain of the ankle. In the serrapeptase group, the swelling decreased by 50 percent on the third post-operative day, while in the control groups (no treatment and treatment with ice) no reduction in swelling occurred. A decrease in pain correlated for the most part with the reduction in swelling. On the basis of these results, serrapeptase would appear to be an effective preparation for the post-operative reduction of swelling, in comparison with classical conservative measures, such as the application of ice.4

Reducing the amount of pain is only one aspect of how systemic enzymes can function. Chronic inflammation is often the root cause of a number of conditions and controlling the process can help alleviate symptoms.

One study compared blood laboratory values before and after supplementation of Exclzyme (a blend containing enzymes serrapeptase, bromelain, lipase, amylase and other proteases) in patients with inflammation related to rheumatic disease or trauma. Results showed a significant decrease in erythrocyte sedimentation rate (ESR), a long-term predictor of cardiovascular disease. ESR is a measurement comparable to C-reactive protein (CRP) levels in predicting risk of a cardiac event. However, ESR does not change as rapidly as does CRP, and CRP is not affected by other factors, as is ESR.5,6

The efficacy of serrapeptase was evaluated in a multi-centre, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After three to four days of treatment, significant symptom regression was observed in serrapeptase-treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all of the symptoms examined. It was concluded that serrapeptase has anti-inflammatory, anti-edemic and fibrinolytic activity, and acts rapidly on localized inflammation.7

Bromelain, a proteolytic enzyme extracted from pineapple, has also been found to be effective in reducing inflammation by blocking chemical signals called cytokines, which promote and increase inflammation.8,9 Research shows bromelain disrupts the migration of neutrophils (a type of white blood cell) to an inflamed area, where they would otherwise propagate the process. One study measured a 50-85 percent decrease in the migration of neutrophils after bromelain treatment.10

Blood viscosity is an important consideration when assessing circulating fibrin and fibrin-nodule deposits that arise during disease progression. Serrapeptase has demonstrated the ability to cleanse the blood by removing excess fibrin from circulation, thus reducing blood stickiness and the threat of blood clot formation. Additionally, toxic substances and remnant large food particles can be further degraded in the blood and prepared for filtration through the liver and expulsion.11

1. Klein G, Kullich W. Reducing pain by oral enzyme therapy in rheumatic diseases. Wien Med Wochenschr. 1999; 149(21-22):577-80.
2. Panagariya A, Sharma AK. A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 2000; 48(11):1130.
3. Bracale G, Selvetella L. Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase[Article in Italian] Minerva Cardioangiol. 1996; 44(10):515-24.
4. Esch PM, Gerngross H, Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase– a prospective study (German). Fortschr Med. 1989; 107(4):67-8, 71-2.
5. Patki M. Study of anti-inflammatory and analgesic efficacy of Exclzyme ™ EN. J Orthopedics. 1999; 33(4):157-170.
6. Andresdottir MB, Sigfusson N, Sigvaldason H, Gundnason V. Erythrocyte Sedimentation Rate, an Independent Predictor of Coronary Heart Disease in Men and Women. Am J Epidemiol. 2003; 158(9):844-851.
7. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88.
8. Onken JE, Greer PK, Calingaert B, et al. Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro. Clin Immunol. 2008; 126(3):345-352.
9. Secor ER, Carson WF, Singh A, et al. (2008) Oral bromelain attenuates inflammation in an ovalbumin-induced murine model of asthma. Evid Based Complement Alternat Med. 2008; 5(1):61-69.
10. Fitzhugh DJ, Shan S, Dewhirst MW et al. Bromelain treatment decreases neutrophil migration to sites of inflammation. Clin Immunol. 2008; 128:66-74.
11. Ernst E., Matrai A. Oral Therapy with proteolytic enzymes for modifying blood rheology. Klin Wschr. 1987; 65:994.
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